Tuberculosis is one of the most deadly diseases caused
by bactery in the world. It has been an
epidemic in all part of the world since hundreds years ago. It has killed
millions people. But thank god, it has decreased due to the finding of the suitable
antibiotic for M. tbc.
But now, human poses
a newly substantial threat by the reemergence of tuberculosis epidemic in the
world. There are so many tuberculosis bactery
get resistant with regular antibiotic.
There are multidrug resistant tuberculosis (MDR-TB) and extensively
drug-resistant tuberculosis (XDR).
MDR TB is defined as TB caused by M. Tbc that are resistant
to two main drug of tuberculosis, isoniazid and rifampin. XDR TB is defined as
MDR-TB plus resistance to a fluoroquinolone, and at least one second-line
injectable agent (amikacin, kanamycin, or capreomycin). MDR-TB is the main cause of failure in the
treatment of TB category 1 by regimen that considered by the World Health
Organization, in patients who are treated under strict observation.
You can guess what will happen when all cases of TB become
MDR TB. Yes, tuberculosis will be very hard to treat. Human will need the newly
regimen of treatment. Discovery of new drug is very costly. And it doesn’t
always result the real new drug. MDR-TB requires prolonged therapy with some new combination with second-line
anti TB drugs. Many of them are less effective, more toxic, and more expensive
than first-line drugs.
What happens when TB is hard to treat? Like I said before,
we will pose a new threat of the
reemergence of tuberculosis epidemic.
Tuberculosis is highly contagious disease.it will support the likelihood
of the occurrence. In the past it has
killed million people. Currently, nearly half a million cases of MDR-TB emerge
every year in the world due to the improper
treatment of TB patient. WHO reported, in
2008, the global mean rate of MDR was 2,9 % among new patients and 15,3 % among
previously treated patients.
Written by : dr. Amrizal Muchtar
Makassar
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